In Communion with God, John Owen wrote:
The Holy Spirit enables believers to obey cheerfully, willingly and patiently to the end. In a word, in all that concerns us in this life and in all our expectation of another life, we will always stand in need of the comfort and strength of the Holy Spirit.
Without the comfort and strength of the Holy Spirit, we will either despise afflictions or collapse under them and God’s purpose in sending them to us will be defeated.
Without the comfort and strength of the Holy Spirit, sin will either harden us so that we treat it with contempt, or else cast us into despair and so we neglect the gracious means that God has graciously provided us with to defeat it.